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. 2022 Feb 17;16:830884. doi: 10.3389/fnins.2022.830884

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Copyright © 2022 Nilsson, Tebani, Malmodin, Pedersen, Hellgren, Löfqvist, Hansen-Pupp, Uhlén and Hellström.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between enteral nutrition and serum metabolites. (A) Spearman correlation (95% confidence interval) between energy provided as enteral nutrition day 1–28 and mean daily metabolite levels during the corresponding period (n = 69). Triangles indicate metabolites that significantly (p < 0.05) correlate with enteral energy intake and the color of the symbols reflect the negative logarithm of the p-value. (B–E) Boxplots show mean daily levels of selected metabolites that depend on the total energy provided as enteral energy. Infants have been dichotomously grouped if they received above (n = 34) or below (n = 35) the median amount of total energy as enteral energy day 1–28. Y-axis shows normalized NMR signal. p-values have been false discovery rate adjusted using the Benjamini–Hochberg method.