Table 2.

The detailed information related to the modulation of NF-κB signaling mediated by HBX.

Target molecules	The role of HBX on target molecules	The regulated molecules in NF-κB signaling	The role of HBX on NF-κB signaling	Biological Functions	References
p65	activation	p65	activation	HBV replication	(142–144)
IkBα	inhibition	IkBα	activation	Signal transduction activation	(145)
p65	interaction	p65	activation	Inflammation, tumorigenesis	(146)
IKKγ	interaction	IKKγ	activation	Signal transduction activation	(86, 147)
IKKα	upregulation	IKKα	activation	Inflammatory cytokine production	(148)
IKKβ	activation	IKKβ	activation	Cellular proliferation	(149)
ECSIT	interaction	IKK α/β, IκBα, p65, p50	activation	Signal transduction activation	(75)
VBP1	interaction	Unknown	activation	Cellular proliferation	(150)
VCP	interaction	Unknown	activation	Signal transduction activation	(151)
AIB1	interaction	Unknown	activation	Signal transduction activation	(152)
PI3-K	activation	p50, p65, IKKα	activation	Cellular motility	(153, 154)
ERK	activation	p50, p65	activation	Inflammatory responses	(155)