Figure 2.

Schematic representation of extrinsic apoptotic pathways and mode of action of therapeutic peptides during MIRI. Schema presenting the signaling apoptotic cascades activated during MIIR involving receptor-dependent pathways in the myocardium. The positive feedback loops regulating DAXX nucleic-cytoplasmic ratio is showed in dark gray. Tat-DAXXp treatment administered at the onset of reperfusion (highlighted in green) can inhibit both the extrinsic and intrinsic pathways. FAS, First Apoptosis Signal; FADD, Fas-Associated protein with Death Domain; DAXX, Death-domain associated protein-6; DISC, death-inducing signaling complex; RIPK1/3, Receptor-interacting serine/threonine-protein kinase 1/3; FLIP, FLICE-inhibitory protein; cIAP, cellular inhibitor of apoptosis proteins 1; ASK1, Apoptosis Signal regulating Kinase 1; JNK, c-Jun N-terminal Kinase; HIPK, homeodomain-interacting protein kinase.