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. 2022 Feb 17;9:825567. doi: 10.3389/fmed.2022.825567

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Copyright © 2022 Versace, Bitto, Ioppolo, Aragona, La Rosa, Roberts, D'Angelo, Cinquegrani, Cirmi, Irrera, Navarra, Corrao, Gangemi and Bagnato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–F) Linear regression results for IL-13 and IL-33 and pulmonary function tests: both IL-13 and IL-33 levels were significantly associated with DLco (circle), TLC (square) and FVC (triangle) in systemic sclerosis (SSc) patients (A,B). A significant direct association was observed between IL-33 levels and modified Rodnan skin score in the entire cohort of SSc patients (C). IL-13 and IL-33 were plotted, respectively, on the left and right ordinate of each image to show the difference in concentrations according to the 70% cut-off for DLco (D), FVC (E) and TLC (F) for SSc patients. *p < 0.05.