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. 2022 Feb 17;16:848079. doi: 10.3389/fnins.2022.848079

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Copyright © 2022 Xue, Cui, Guo, Beltz, Zhao, Zhang and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voluntary exercise prevented hypertensive response sensitization to angiotensin (ANG) II treatment although the locomotor activities of the rats were elevated. HRs were comparable in all groups of offspring. Daily and averaged mean arterial pressure (MAP, A,B), heart rate (HR, C,D) and locomotor activity (E,F) in sedentary (Blocked) or exercise (Running) rats during the Induction-Delay-Expression (I-D-E) paradigm. (n = 5/group; two-way ANOVA was used for analysis followed by Tukey’s post-hoc tests. p < 0.05, * vs. baseline; # vs. blocked I-S + E-ANG II and running rats; -I vs. blocked rats).