Table 1.

TRAFs-associated receptor and ligand pairs.

TRAF1		TRAF2		TRAF3		TRAF5		TRAF6
Receptor	Ligand	Receptor	Ligand	Receptor	Ligand	Receptor	Ligand	Receptor	Ligand
TNFR1	TNF, LTα	TNFR1	TNF, LTα	TNFR2	TNF, LTα	TNFR1	TNF, LTα	TNFR2	TNF, LTα
TNFR2	TNF, LTα	TNFR2	TNF, LTα	4-1BB	4-1BB ligand	TNFR2	TNF, LTα	CD40	CD40 ligand
4-1BB	4-1BB ligand	4-1BB	4-1BB ligand	AITR	AITR ligand	CD27	CD27 ligand	p75	NGF, BDNF, neurotrophins
AITR	AITR ligand	AITR	AITR ligand	BCMA	APRIL, THANK	CD40	CD40 ligand	RANK	RANKL
BCMA	APRIL, THANK	BCMA	APRIL, THANK	CD27	CD27 ligand	HVEM	LIGHT, LTα	TACI	APRIL, THANK
HVEM	LIGHT, LTα	CD27	CD27 ligand	CD40	CD40 ligand	LTβR	LTβ	TLR2	PAMPs
OX40	OX40 ligand	GITR	GITR ligand	HVEM	LIGHT, LTα	OX40	OX40 ligand	TLR3	dsRNA
p75	NGF, BDNF, neurotrophins	CD40	CD40 ligand	OX40	OX40 ligand	p75	NGF, BDNF, neurotrophins	TLR4	LPS
RANK	RANKL	HVEM	LIGHT, LTα	LTβR	LTβ	RANK	RANKL	TLR7	ssRNA
CD40	CD40 ligand	OX40	OX40 ligand	p75	NGF, BDNF, neurotrophins	TACI	APRIL, THANK	TLR9	CpG DNA
XEDAR	EDA	p75	NGF, BDNF, neurotrophins	RANK	RANKL	NOD1	PAMPs/DAMPs	NOD1	PAMPs/DAMPs
TLR3	dsRNA	RANK	RANKL	TLR3	dsRNA	NOD2	PAMPs/DAMPs, viral ssRNA	NOD2	PAMPs/DAMPs, viral ssRNA
TLR4	LPS	TACI	APRIL, THANK	TLR4	LPS	RIG-I	PAMPs/DAMPs, viral RNA	RIG-I	PAMPs/DAMPs, viral RNA
		CD30	CD30 ligand	TLR7	ssRNA	IL-17R	IL-17	IFNλR1,	IFNλ
		NOD1	PAMPs/DAMPs	TLR9	CpG DNA	IL-6R	IL-6	TβRI, TβRII	TGF-β
		NOD2	PAMPs/DAMPs, viral ssRNA	NOD1	PAMPs/DAMPs	Troy		IL-1R	IL-1β
		RIG-I	PAMPs/DAMPs, viral RNA	RIG-I	PAMPs/DAMPs, viral RNA			IL-2R	IL-2
		IFNAR1	IFN	IL-6R	IL-6			IL-17R	IL-17
		IL-6R	IL-6	IL-17R	IL-17			Troy
		IL-17R	IL-17
		Troy

TRAFs-associated receptors are shown in the left column while ligands for TRAFs-associated receptors are shown in the right column.