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. 2022 Feb 17;9:842885. doi: 10.3389/fcvm.2022.842885

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Copyright © 2022 Fang, Li, Li, Luo, Kuang, Luo, Li, Yang, Liu, Deng, Xue, Wu and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the mechanism for the decrease of I_Ca,L induced by HHP. Piezo1 activated by HHP depressed I_Ca,L contributing to increased AF susceptibility through the CaM/Src/Pitx2 pathway.