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. 2022 Feb 17;13:803080. doi: 10.3389/fnagi.2021.803080

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Copyright © 2022 Pan, Wang, Wu, Jin, Cao, Qiu, Teng, Li, Shao, Huang, Wu, Xiang, Chen, Liu, Tang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mean FC between the brain regions of the hate circuit in the patient group. One-sample t-tests on the FCs were conducted. The warm color denotes higher FC values, and the cold color denotes lower FC in the patients. (B) Mean FC between the brain regions of the hate circuit in the control group. The range from red to green denotes higher FC values. Blue and purple denote lower FC. One-sample t-tests on the FCs were conducted. (C) Increased FC between the left insula and the right insula, between the left putamen and the right putamen, between the left SFG and the right SFG and decreased FC values in the right insula and the left SFG were observed in patients with MDD relative to healthy controls. FC, functional connectivity; SFG, superior frontal gyrus; MDD, major depressive disorder.