Table 1.
Baseline clinical and laboratory data of the study population
|
|
PPA (n = 91)
|
NSBB responders (n = 60)
|
NSBB non-responders (n = 31)
|
P
value
|
| Male sex n (%) | 65 (71.4) | 44 (73.3) | 21 (67.7) | 0.371 |
| Age (years) | 55.16 ± 4.0 | 55.43 ± 3.74 | 54.64 ± 4.57 | 0.382 |
| Ascites n (%) | 29 (31.9) | 19 (31.7) | 10 (32.3) | 0.571 |
| HB (g/dL) | 11.07 ± 1.44 | 11.10 ± 1.66 | 11.02 ± 0.91 | 0.812 |
| Platelets (× 103/mm3) | 83.13 ± 12.33 | 85.32 ± 15.46 | 78.90 ± 12.19 | 0.022 |
| WBCs (× 103/mm3) | 4.85 ± 1.05 | 4.88 ± 1.11 | 4.78 ± 0.96 | 0.662 |
| ALT (IU/L) | 40.01 ± 9.74 | 40.75 ± 9.98 | 38.58 ± 9.23 | 0.322 |
| AST (IU/L) | 54.40 ± 14.00 | 55.48 ± 14.24 | 52.29 ± 13.47 | 0.312 |
| APRI-score | 1.94 ± 0.46 | 1.92 ± 0.30 | 1.97 ± 0.56 | 0.632 |
| Albumin (g/dL) | 2.94 ± 0.18 | 2.93 ± 0.17 | 2.97 ± 0.18 | 0.252 |
| Bilirubin (mg/dL) | 1.73 ± 0.62 | 1.65 ± 0.55 | 1.89 ± 0.72 | 0.112 |
| INR | 1.35 ± 0.18 | 1.34 ± 0.17 | 1.39 ± 0.16 | 0.192 |
| CTP A/B/C | 48/36/7 | 34/22/4 | 14/14/3 | 0.563 |
| Baseline PVCI | 0.533 ± 0.10 | 0.545 ± 0.11 | 0.509 ± 0.09 | 0.112 |
| Baseline esophageal varices grade: n (%) | ||||
| Small | 17(18.7) | 10 (16.7) | 7 (22.6) | 0.061 |
| Medium | 48 (52.7) | 28 (46.6) | 20 (64.5) | |
| large | 26 (28.6) | 22 (36.7) | 4 (12.9) | |
| Baseline portal hypertensive gastropathy grade: n (%) | ||||
| No | 26 (28.6) | 13 (21.7) | 13 (41.9) | 0.0121 |
| Mild | 32 (35.2) | 19(31.7) | 13 (41.9) | |
| Severe | 33 (36.2) | 28 (46.6) | 5 (16.2) | |
| GV presence n (%) | 14 (15.4) | 12 (20.0) | 2 (6.5) | 0.083 |
| NSBB dose (min-max): (mg/d) | 64.84 ± 14.63 (30-100) | 65.33 ± 15.45 (30-100) | 63.87 ± 13.08 (40-80) | 0.652 |
1
Chi-square test.
2
Independent sample t-test.
3
Fisher’s exact test.
ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase/platelet ratio index; AST: Aspartate aminotransferase; β-Arr-2: β-Arrestin-2; CI: Congestion index; CTP: Child-Turcotte-Pugh class; GV: Gastric varices; HB: Hemoglobin; INR: International normalization ratio; ITA: Intention to treat analysis; Max: Maximum; Min: Minimum; NSBB: Nonselective beta-blocker; PPA: Per-protocol analysis; WBCs: White blood cells.