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. 2022 Feb 17;13:820267. doi: 10.3389/fneur.2022.820267

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Copyright © 2022 De Feo, Hämäläinen, Manninen, Immonen, Valverde, Ndode-Ekane, Gröhn, Pitkänen and Tohka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between the hippocampal volumes (mm³) for each dataset and time point between sham and TBI animals. Note the different dynamics in ipsilateral hippocampal volume changes between the EpiBioS4Rx and EPITARGET animals, particularly at 2 days post-injury. The rats in the EpiBioS4Rx cohort were anesthetized with 4% isoflurane at the time of injury. The rats in the EPITARGET cohort were anesthetized with pentobarbital-based anesthesia cocktail, which apparently reduced the acute post-impact seizure-related swelling better than isoflurane.