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. 2022 Feb 21;28(7):755–762. doi: 10.3748/wjg.v28.i7.755

Table 1.

Case descriptions of gastrocnemius myalgia syndrome reported in Crohn’s disease

Ref.
Age (yr)/sex at GMS onset
Initial presentation, time-to-onset
Active CD at time of GMS dx
CK serum level
Biopsy
Treatment
Corticosteroids-dependence (d) or resistance (r)
Ménard et al[8], 1976 44/M Muscular, 2 mo No N Granulomatous myositis PDS1 (80 mg/d) No
Gilliam et al[13], 1981 19/M Digestive, 6 mo Yes N Necrotizing vasculitis PDS1 (60 mg/d) No
Hall et al[10], 1985 32/F Muscular, 120 mo Yes N Non-granulomatous myositis 5-ASA1, PDS1 (25 mg/d) No
Drabble and Gani[14], 1992 50/M Digestive, 168 mo Yes N Not performed Hydrocortisone1 (400 mg/d), PDS1 No
Disdier et al[11], 1997, Case 1 26/F Muscular, 48 mo Yes N Necrotizing vasculitis PDS1 (60 mg/d), CYC1, 5-ASA1 Yes (r)
Disdier et al[11], 1997, Case 2 21/F Simultaneous Yes N Vasculitis PDS (1 mg/kg/d), AZA1 Yes (d)
Christopoulos et al[3], 2003 19/F Simultaneous Yes N Granulomatous myositis PDS1 (0.5 mg/kg/d) No
Ullrich et al[15], 2009 25/F Digestive, 84 mo Yes N Vasculitis PDS (50 mg/d), AZA, IFX1 Yes (d)
Co et al[16], 2010 15/F Digestive, 8 mo Yes N Not performed IFX1 /
Mogul et al[17], 2010 15/M Digestive, 60 mo No N Non-granulomatous myositis PDS1 (40 mg/d), MTX1 No
Piette et al[18], 2010 45/M Simultaneous Yes (3-13 × N) Vasculitis PDS1 (1 mg/kg/d) No
Goldshmid et al[19], 2011 24/F Simultaneous Yes (330 U/L) Not performed MPDS (100 mg/d), IFX1, AZA1 Yes (d)
Vadala di Prampero et al[20], 2016 26/M Digestive, 72 mo Yes N Non-granulomatous myositis PDS (60 mg/d), AZA1 (chronic), Adalimumab1 Yes (d)
Saffar[12], 2017 33/F Digestive, 120 mo Yes N Not performed PDS, IFX1 Yes (r)
Osada et al[9], 2018 38/M Digestive, 3 mo Yes N Non-granulomatous myositis PDS, AZA1, 5-ASA1 Yes (d)
Current case 33/F Simultaneous Yes N Granulomatous myositis MDPS (0.8/kg/d), IFX1 Yes (d)
1

These treatment modalities are those that induced a persistent remission of myositis-related symptoms.

GMS: Gastrocnemius myalgia syndrome; CD: Crohn’s disease; MDPS: Mitochondrial-derived peptides; IFX: Infliximab; ASA: Aminosalicylate; AZA: Azathioprine; PDS: Peroxydisulfate.