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. 2022 Mar 3;16(2):128–145. doi: 10.1007/s13206-022-00052-5

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© The Korean BioChip Society 2022

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 4 — Synthetic-polymer-based nanoparticles for cancer therapy and vaccination. a Mice harboring two CT26 colon carcinoma tumors were treated intratumorally in one of the tumors with either Ox40l + Cd80/86 mRNA-CARTs or control mRNA-CARTs (Reproduced with permission from [52]

Copyright 2019, Cancer Research). b Design of macrophage-targeted polymeric NPs based on poly(beta-amino ester) formulated with mRNAs encoding key regulators of macrophage polarization (Reproduced with permission from [53] Copyright 2019, Nature Communication). c Graphical abstract of polyglucin:spermidine conjugate as a carrier of an mRNA-RBD vaccine encoding the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (reproduced with permission from [59] Copyright 2021, Vaccines). d Responsivity of PMs (PEG-PAsp(DET/GlcAm) to ATP. Gel electrophoresis was performed after incubation of PMs with several concentrations of ATP (reproduced with permission from [61] Copyright 2021, Journal of Controlled Release)