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. 2022 Mar 3;16(2):128–145. doi: 10.1007/s13206-022-00052-5

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© The Korean BioChip Society 2022

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 5 — mRNA delivery systems formulated with peptide-derived and inorganic nanoparticles. a Pulmonary delivery of mRNA formulations with different transfection agents (naked mRNA, PEG-KL4/mRNA, and lipoplex/mRNA). At 24 h post-administration, the lungs were isolated for bioluminescence imaging, and luciferase protein expression of lung tissues were measured (Reproduced with permission from [1]

Copyright 2019, Journal of Controlled Release). b Graphical abstract of cell-penetrating peptide (CPP) PepFect 14 (PF14)-mRNA nanoparticles in models of ovarian cancer (Reproduced with permission from [67] Copyright 2019, European Journal of Pharmaceutics and Biopharmaceutics). c Illustration of the fully functionalized SeNP (Reproduced with permission from [74] Copyright 2021, Pharmaceutics). d Actual sizes of representative tumors after xenograft implantation followed by injection of 5 nM AuNP-αRNA I-5’BAX mRNA in mice (reproduced with permission from [75] Copyright 2013, PLOS ONE)