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. 2022 Mar 3;16(2):128–145. doi: 10.1007/s13206-022-00052-5

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© The Korean BioChip Society 2022

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 6 — Efficient mRNA delivery by hybrid nanoparticles. a The tolerability of the mRNA encapsulated in MOF-PGMA(EA) or PGMA(EA) complexes (at an N/P ratio of 1.5) in the presence of 10% FBS (reproduced with permission from [80]

Copyright 2018, Chemical Communication). b Synthesis of the azobenzene-unit-containing metal–organic-framework-based nanoprobe (AMOF@MBs) (reproduced with permission from [82] Copyright 2019, Analyst). c mBim/DMP-039 complex suppressing the C26 subcutaneous xenograft model in vivo (reproduced with permission from [88] Copyright 2021, International Journal of Nanomedicine). d mRNA complexes stimulate innate immunity through PRR activation. Evaluation of PRR activation via the TLR7 and TLR3 pathways in HEK-Blue hTLR7 and HEK-Blue hTLR3 cells with mRNA formulations (reproduced with permission from [90] Copyright 2019, Biomaterials)