Table 2.
Peptide-derived nanoparticles for efficient RNA therapeutics transfection and RNA-based cancer therapy
| Type | Delivery vehicle | Therapeutic modality | Target | Ref |
|---|---|---|---|---|
| Peptide-derived NP | HK (histidine-lysine) peptide | mRNA | Increased mRNA transfection in vitro | [64] |
| PEG-KL4 peptide | Inhalable dry powder for mRNA pulmonary delivery | [1] | ||
| OAA with s–s building block | Enhanced transfection efficiency and tolerability | [65] | ||
| CPP PepFect 14 | Induction of specific proteins in ovarian cancer | [67] | ||
| AmPPD | siRNA | Effective therapy in prostate cancer model | [68] | |
| p5RHH NP | Targeting drivers of tumor progression pancreatic adenocarcinoma model | [69] | ||
| chimeric peptide NP | miRNA | Plectin-1 targeted delivery in pancreatic cancer | [70] |