TABLE 4.
Effect of UL54 mutations in antiviral susceptibilities of recombinant CMV isolatesa
| Region | Mutation | Amino acid change | Viral phenotypeb
|
||
|---|---|---|---|---|---|
| Ganciclovir | Foscarnet | Cidofovir | |||
| IV | N408D | Asparagine to aspartic acid | R | S | R |
| F412C | Phenylalanine to cysteine | R | S | R | |
| F412V | Phenylalanine to valine | R | S | R | |
| ∂-region C | L501I | Leucine to isoleucine | R | S | R |
| K513E | Lysine to glutamic acid | R | S | R | |
| P522S | Proline to serine | R | S | R | |
| L545S | Leucine to serine | R | S | R | |
| D588E | Aspartic acid to glutamic acid | S | R | S | |
| II | T700A | Threonine to alanine | S | R | S |
| V715M | Valine to methionine | S | R | S | |
| VI | V781I | Valine to isoleucine | S | R | S |
| III | L802M | Leucine to methionine | S | R | S |
| K805Q | Lysine to glutamine | S | S | R | |
| A809V | |||||
| T821I | Threonine to isoleucine | R | S | R | |
| V | A987G | Alanine to glysine | R | S | R |
| Other | S676G | Serine to glysine | S | S | S |
| V759M | Valine to methionine | S | S | S | |
| Multiple | F412C L802M | R | R | R | |
| K513E D588E | R | R | R | ||
| K805Q T821I | R | R | R | ||
a
Data are from reference 16.
b
R and S denote resistant and sensitive, respectively.