TABLE 5.

Antiviral susceptibilities of reference CMV strains

Methoda	Ganciclovir IC50 (μM) to:		Foscarnet IC50 (μM) to:		Cidofovir IC50 (μM) to:		Reference
	AD169b	759rD100c	AD169	759rD100	AD169	759rD100
PRA	3.1						17
	1	12	150	150			6
	4.9	35	64	24	0.6		61
	4		210		0.54		64
	10		250		1		47
	5.3	58.9d					52
	2.5	55					10
	10		200		0.5		48
					0.6		10
DNA	1.7	39	50	35	0.49	1.5	61
	0.7	19					8
LARA	6.5	31.6d					52
ELISA	5.4		150				67
	6.25		210		1		47

^aPRA, plaque reduction assay; DNA, DNA hybridization assay; LARA, late-antigen reduction assay. 

^bSusceptible CMV strain that contains UL97 and DNA polymerase wild-type sequences. 

^cGanciclovir-resistant CMV strain that contains a UL97 deletion and a DNA polymerase mutation. 

^dGanciclovir-resistant strain RCL1 was used.