TABLE 6.

Ganciclovir, foscarnet, and cidofovir IC₅₀s used in clinical studies to define resistant CMV isolates

Method	IC50 (μM) of:			Reference(s)
	Ganciclovir	Foscarnet	Cidofovir
Plaque reduction assay	≥9			30
	≥9	≥300		57
	≥8	≥324	≥2.1	11, 58, 59
	≥12	≥400		62
	≥12			70
	≥6	≥400	≥2	15
DNA hybridization assay	5 times higher than IC50 for AD169			12
	>6			13
	>6	>400	≥2	14, 30