. 2022 Feb 17;14:818597. doi: 10.3389/fnagi.2022.818597

TABLE 2.

Macular vessel density in HC and patients with PD.

Macular parameters	All participants		p^a values	H-Y I	H-Y II	H-Y III	p^b values	p values
	HC	PD						H-Y I vs. HC	H-Y II vs. HC	H-Y III vs. HC
Fovea	9.25 (8.48, 10.50)	8.20 (7.70, 9.10)	<0.001 ^*	8.50 (7.90, 9.53)	8.20 (7.70, 9.03)	7.90 (7.00, 8.70)	0.035 ^†	0.186^*	<0.001 ^‡	<0.001 ^*
SI	18.00 (17.28, 18.73)	17.40 (16.80, 18.10)	0.014^*	17.85 (17.00, 18.45)^‡⁣‡	17.35 (17.00, 18.00)^‡⁣‡	16.50 (14.50, 17.30)^^,^†⁣†	<0.001 ^‡	0.591^*	0.012 ^‡	<0.001 ^*
II	18.40 (17.55, 18.93)	18.00 (17.40, 18.60)	0.038^‡	18.20 (17.68, 18.73)^‡⁣‡	18.00 (17.50, 18.60)^‡⁣‡	16.60 (15.00, 17.70)^^,^†⁣†	<0.001 ^‡	0.575^*	0.172^*	<0.001 ^‡
NI	18.70 (18.00, 19.20)	18.40 (17.80, 18.80)	0.026^‡	18.60 (18.18, 18.90)^‡⁣‡	18.40 (18.00, 18.90)^‡⁣‡	17.20 (16.00, 18.00)^^,^†⁣†	<0.001 ^‡	0.595^‡	0.174^*	<0.001 ^‡
TI	17.80 (16.98, 18.60)	16.90 (16.50, 17.70)	<0.001 ^*	17.25 (16.70, 17.93)^‡⁣‡	16.80 (16.48, 17.90)^‡⁣‡	15.90 (14.90, 17.00)^^,^†⁣†	<0.001 ^‡	0.292^*	0.012 ^*	<0.001 ^*
SO	18.25 (17.68, 18.70)	17.90 (17.20, 18.50)	0.020^‡	18.10 (17.48, 18.50)	17.80 (17.20, 18.50)	17.10 (16.00, 18.40)	0.073^‡	0.348^‡	0.103^*	0.003 ^‡
IO	18.70 (18.43, 19.00)	18.40 (17.80, 18.90)	0.006^‡	18.55 (17.98, 18.93)	18.35 (17.80, 19.00)	17.80 (16.80, 18.80)	0.116^‡	0.219^‡	0.026 ^*	0.003 ^‡
NO	19.60 (18.90, 19.83)	19.10 (18.40, 19.80)	0.021^‡	19.10 (18.60, 19.80)	19.40 (18.38, 19.80)	18.70 (17.00, 19.50)	0.108^‡	0.182^*	0.069^*	0.002 ^‡
TO	17.50 (16.70, 18.03)	17.10 (16.30, 17.80)	0.046^‡	17.60 (16.98, 18.05)^†⁣†, ^‡⁣‡	16.85 (16.28, 17.40)^**	16.00 (14.30, 17.10)^**	<0.001 ^‡	0.617^*	0.033 ^*	<0.001 ^‡
FAZ	0.36 (0.32, 0.39)	0.29 (0.26, 0.33)	<0.001 ^*	0.31 (0.28, 0.34)^‡⁣‡	0.28 (0.26, 0.32)^‡⁣‡	0.24 (0.22, 0.27)^^,^†⁣†	<0.001 ^†	<0.001 ^*	<0.001 ^*	<0.001 ^*
Inner ring	18.10 (17.58, 18.80)	17.70 (17.20, 18.30)	0.005^‡	18.05 (17.60, 18.35)^‡⁣‡	17.75 (17.28, 18.30)^‡⁣‡	16.50 (15.40, 17.50)^^,^†⁣†	<0.001 ^‡	0.324^*	0.030 ^*	<0.001 ^‡
Outer ring	18.50 (18.10, 18.80)	18.20 (17.50, 18.70)	0.020^‡	18.30 (17.78, 18.80)^‡⁣‡	18.20 (17.60, 18.60)	17.20 (16.40, 18.80)^**	0.032 ^‡	0.500^‡	0.012 ^*	0.002 ^‡

Significant results appear in bold. p^a: p-value for comparison between HC and PD; p^b: p-value for comparison among the three PD subgroups. *Student’s t-test; ^†One-way ANOVA; ^‡Non-parametric test.

Intergroup significant difference in Post Hoc Analysis: **Compared with H-Y I stage group; ^†⁣†Compared with H-Y II stage group; ^‡⁣‡Compared with H-Y III stage group. The Benjamini-Hochberg Adjusted p-value was calculated to defend the false discovery rate (FDR), and the FDR was set at 0.05.

PD, Parkinson’s disease; HC, healthy controls; SI, Superior inner; II, Inferior inner; NI, Nasal inner; TI, Temporal inner; SO, Superior outer; IO, Inferior outer; NO, Nasal outer; TO, Temporal outer; FAZ, Foveal avascular zone.