Figure 6.
Genetic landscape of osimertinib-resistant PDXs and PDCs. (a) Oncoplot of somatic SNV mutations. (b) Copy number variations per sample. (c) The synergistic antitumor efficacy of combination of osimertinib, MEK inhibitor, and PI3K inhibitor in PDX harboring acquired KRAS G12D mutation. Mice were treated with osimertinib 25 mg/kg, trametinib 0.5 mg/kg, and buparlisib 35 mg/kg once daily for 3 weeks after the tumor volume reached 200 mm 3 . Data represent the mean ± SEM (n = 5/group). *p < 0.05. (d) The body weight change in PDX harboring acquired KRAS G12D mutation. Mice were treated with osimertinib 25 mg/kg, trametinib 0.5 mg/kg, and buparlisib 35 mg/kg once daily for 3 weeks after the tumor volume reached 200 mm 3 . Data represent the mean ± SEM (n = 5/group). *p < 0.05.