Table 1.
Regression coefficients and p values for the EORTC QLQ-C30 domains in which linear models were favored in the ITT population, with WPL as the dependent variable.
| EORTC QLQ-C30 item/domain | MID for deterioration | Regression coefficient (95% CI) |
p value of regression coefficient |
|---|---|---|---|
| Global Health Status | 8 | −6.24 (−6.78, −5.70) |
<0.001 |
| Role Functioning | 6 | −3.92 (−4.28, −3.57) |
<0.001 |
| Emotional Functioning | 6 | −2.93 (−3.34, −2.52) |
<0.001 |
| Cognitive Functioning | 4 | −1.35 (−1.66, −1.04) |
<0.001 |
| Social Functioning | 7 | −4.12 (−4.56, −3.68) |
<0.001 |
| Fatigue | 8 | 4.84 (4.31, 5.37) |
<0.001 |
| Nausea and Vomiting | 11 | 3.93 (2.76, 5.09) |
<0.001 |
| Insomnia | 15 | 3.11 (2.38, 3.84) |
<0.001 |
| Constipation | 3 | 0.36 (0.17, 0.55) |
<0.001 |
| Diarrhea | 4 | 0.55 (0.23, 0.87) |
<0.001 |
| Financial Difficulties | 5 | 1.38 (1.06, 1.70) |
<0.001 |
CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life questionnaire; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.
Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.