Table 2.
Regression coefficients and p values for the EORTC QLQ-C30 domains in which quadratic models were favored in the ITT population, with WPL as the dependent variable.
| Linear coefficient (β1) |
Quadratic coefficient (β2) |
||||
|---|---|---|---|---|---|
| EORTC QLQ-C30 item/domain | MID for deterioration | Regression coefficient (95% CI) |
p value | Regression coefficient (95% CI) |
p value |
| Physical Functioning | 10 | −11.08 (−12.43, −9.73) |
<0.001 | −0.41 (−0.72, −0.10) |
0.009 |
| Pain | 17 | 7.37 (6.08, 8.66) |
<0.001 | 0.90 (0.42, 1.37) |
<0.001 |
| Dyspnea | 8 | 1.30 (0.46, 2.14) |
0.002 | 0.25 (0.10, 0.39) |
<0.001 |
| Appetite Loss | 14 | 8.49 (6.82, 10.17) |
<0.001 | −0.72 (−1.13, −0.31) |
<0.001 |
CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life questionnaire; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.
Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.