Table 3.
Regression coefficients and p values for the EORTC QLQ-C30 domains from the multivariable correlation analysis in the ITT population (with corresponding MID values for deterioration), with WPL as the dependent variable.
| EORTC QLQ-C30 item/domain | MID for deterioration | Regression coefficient (95% CI) | p value of regression coefficient |
|---|---|---|---|
| Global Health Status | 8 | −3.03 (−3.69, −2.37) | <0.001 |
| Physical Functioning | 10 | −2.47 (−3.68, −1.26) | <0.001 |
| Role Functioning | 6 | −1.34 (−1.83, −0.86) | <0.001 |
| Emotional Functioning | 6 | −0.38 (−0.83, 0.07) | 0.097 |
| Cognitive Functioning | 4 | −0.02 (−0.31, 0.28) | 0.92 |
| Social Functioning | 7 | −0.78 (−1.32, −0.24) | 0.0047 |
| Fatigue | 8 | 0.20 (−0.48, 0.88) | 0.57 |
| Nausea and Vomiting | 11 | −0.33 (−1.42, 0.77) | 0.56 |
| Pain | 17 | 1.06 (−0.15, 2.26) | 0.086 |
| Dyspnea | 8 | 0.33 (−0.21, 0.87) | 0.23 |
| Insomnia | 15 | 0.02 (−0.69, 0.72) | 0.96 |
| Appetite Loss | 14 | 1.73 (0.78, 2.68) | <0.001 |
| Constipation | 3 | −0.04 (−0.21, 0.13) | 0.65 |
| Diarrhea | 4 | 0.23 (−0.05, 0.52) | 0.11 |
| Financial Difficulties | 5 | 0.21 (−0.09, 0.51) | 0.16 |
CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life questionnaire; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.
Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.