Table 3.

Regression coefficients and p values for the EORTC QLQ-C30 domains from the multivariable correlation analysis in the ITT population (with corresponding MID values for deterioration), with WPL as the dependent variable.

EORTC QLQ-C30 item/domain	MID for deterioration	Regression coefficient (95% CI)	p value of regression coefficient
Global Health Status	8	−3.03 (−3.69, −2.37)	<0.001
Physical Functioning	10	−2.47 (−3.68, −1.26)	<0.001
Role Functioning	6	−1.34 (−1.83, −0.86)	<0.001
Emotional Functioning	6	−0.38 (−0.83, 0.07)	0.097
Cognitive Functioning	4	−0.02 (−0.31, 0.28)	0.92
Social Functioning	7	−0.78 (−1.32, −0.24)	0.0047
Fatigue	8	0.20 (−0.48, 0.88)	0.57
Nausea and Vomiting	11	−0.33 (−1.42, 0.77)	0.56
Pain	17	1.06 (−0.15, 2.26)	0.086
Dyspnea	8	0.33 (−0.21, 0.87)	0.23
Insomnia	15	0.02 (−0.69, 0.72)	0.96
Appetite Loss	14	1.73 (0.78, 2.68)	<0.001
Constipation	3	−0.04 (−0.21, 0.13)	0.65
Diarrhea	4	0.23 (−0.05, 0.52)	0.11
Financial Difficulties	5	0.21 (−0.09, 0.51)	0.16

CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life questionnaire; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.

Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.