Table 4.
Regression coefficients and p values for the EORTC QLQ-BR23 domains in which linear models were favored in the ITT population, with WPL as the dependent variable.
| EORTC QLQ-BR23 item/domain | Sample size | MID for deterioration | Regression coefficient (95% CI) |
p value of regression coefficient |
|---|---|---|---|---|
| Body Image | 329 | 11 | −3.30 (−4.05, −2.56) |
<0.001 |
| Sexual Enjoyment | 233 | 15 | 0.69 (−0.30, 1.67) |
0.17 |
| Future Perspective | 329 | 0.7 | −0.21 (−0.25, −0.18) |
<0.001 |
| Breast Symptoms | 327 | 6 | 2.72 (2.05, 3.39) |
<0.001 |
| Arm Symptoms | 327 | 11 | 3.96 (3.07, 4.84) |
<0.001 |
| Upset by Hair Loss | 237 | 10 | 1.58 (0.91, 2.25) |
<0.001 |
CI, confidence interval; EORTC QLQ-BR23, European Organisation for Research and Treatment of Cancer breast cancer–specific module; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.
Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.