Table 6.
Regression coefficients and p values for the EORTC QLQ-BR23 domains from the multivariable correlation analysis of the ITT population (with corresponding MID values for deterioration), with WPL as the dependent variable.
| EORTC QLQ-BR23 item/domain | MID for deterioration | Regression coefficient (95% CI) |
p value of regression coefficient |
|---|---|---|---|
| Body Image | 11 | −1.10 (−2.75, 0.54) | 0.19 |
| Sexual Functioning | 11 | 0.66 (−0.94, 2.26) | 0.42 |
| Sexual Enjoyment | 15 | −0.62 (−2.30, 1.07) | 0.47 |
| Future Perspective | 0.7 | −0.07 (−0.14, −0.01) | 0.029 |
| Systemic Therapy Side Effects | 10 | 3.35 (1.09, 5.60) | 0.0038 |
| Breast Symptoms | 6 | 1.35 (0.10, 2.61) | 0.035 |
| Arm Symptoms | 11 | 2.16 (0.36, 3.96) | 0.019 |
| Upset by Hair Loss | 10 | 0.53 (−0.39, 1.46) | 0.26 |
CI, confidence interval; EORTC QLQ-BR23, European Organisation for Research and Treatment of Cancer breast cancer–specific module; ITT, intent to treat; MID, minimally important difference; WPL, work productivity loss.
Domains in white background are functional components, and those in gray background are symptomatic components. Statistically significant p values are in bold text.