Figure 1.

BALB/cByJ mice are more sensitive to thermal nociception and mechanical stimulation compared to BALB/cJ mice. (a): By mice showed increased hot plate (53.5°C) sensitivity as indicated via a significant reduction in hind paw lick latencies compared to J (p = 3.61e−11). (b): Female mice showed increased hot plate latencies (p = 4.53e−4). There was no significant Sex x Strain interaction (p = 0.38). (c): By mice were more sensitive to mechanical stimulation than J mice as indicated via a reduced force threshold (g) to initiate a withdrawal response (p = 0.008). (d,e): There was no effect of Substrain in the Hargreaves test (p = 0.173) or cold plate (p = 0.82).