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. 2022 Feb 17;10:836285. doi: 10.3389/fcell.2022.836285

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Copyright © 2022 Zhuang, Zhao, Cheng, Li, Si, Lin and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired HIF-1α expression affects in vivo bone regeneration of mice. (A) The expression of HIF-1α and CD44⁺ cells in the defected region of calvarial bone 20 days after surgery (scar bar: 100 μm). (B) Semi-quantification results of HIF-1α expression. (C) The 2D and 3D images for micro-CT results. (D) HE staining of defected calvarial bone, with shNC or shHIF injection, 20 days after surgery (scar bar: 100 μm). (E) The analysis for bone volume/tissue volume (BV/TV) of micro-CT results. * indicates the significance tests between groups: *p < 0.05.