Figure 2.

Geographical location of specific cell populations define cell-to-cell communication

(A) Dot-plot of gene set enrichment analysis comparing bulk RNA sequencing and spatial transcriptomics of the main clusters (0–4). Black boxes are shown around the point when the gene set enrichment analysis adjusted p value is < 0.1.

(B) Heatmap indicating the physical distance between clusters of the excellent responder (ER) and poor responder (PR) groups, where each square represents a cluster-cluster comparison, the blue range of colors indicates longer distance between clusters, and the red range of colors indicates shorter physical distance between clusters.

(C) Heatmap of ligand-receptor (LR) analysis showing patterns of the top co-expressed LRs between clusters of ER (left) and PR (right).