Figure 10.

Comparison of published mRNA-binding partners for IMP-1. The overlap of mRNA gene lists identified as binding partners for IMP-1 is shown (gene lists provided in Table S3). The general characteristics of the studies are summarized in Table 1. Thus, both studies differ from our study of endogenous IMP-1 in mouse mammary epithelial cells as follows: Jonson et al. (38) and Hafner et al. (39) overexpressed a FLAG-tagged version of IMP-1 in 293T cells, and Hafner et al. analyzed retrieved sequence tags after PAR–CLIP analysis. IMP-1, insulin-like growth factor 2 mRNA-binding protein-1; PAR–CLIP, photoactivatable ribonucleoside–enhanced crosslinking and immunoprecipitation.