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. 2022 Feb 4;25(3):103871. doi: 10.1016/j.isci.2022.103871

Figure 1.

Figure 1

Effect of UVA irradiation on growth factors release in SZ95 sebocytes

(A) Experimental scheme of UVA irradiation of SZ95 sebocytes.

(B) Phase-contrast analysis of SZ95 sebocytes after 4-UVA 5 J/cm2 irradiations.

(C) The mRNA expression levels of POMC, EDN1, SCF, and b-FGF in SZ95 sebocytes after 24 and 48h post 1-UVA and 48h post three or 4-UVA 5 J/cm2 irradiations. Results are presented as the mean ± SD of three independent experiments and are expressed as the fold change respect to untreated control cells (∗p < 0.05, ∗∗p < 0.01).

(D) Protein quantitation by ELISA of α-MSH, EDN1, SCF, and b-FGF in SZ95 sebocytes after 24 and 48h post 1-UVA and 48h post three or 4-UVA 5 J/cm2 irradiations. Results are presented as the mean ± SD of three independent experiments and are expressed in absolute quantities (∗p < 0.05, ∗∗p < 0.01 vs Ctr).

(E) The mRNA expression levels and protein quantitation by ELISA of POMC/α-MSH, EDN1, SCF, and b-FGF in SZ95 sebocytes after 72h or 1 week post 7-UVA 5 J/cm2 irradiations. Data represent the mean ± SD of three independent experiments. For mRNA levels, results are expressed as the fold change respect to untreated control cells (∗∗p < 0.01). For ELISA assay, results are expressed in the absolute quantities (∗∗p < 0.01 vs Ctr).