Table 4.
Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways altered in the jejunum of chickens on a control diet compared to those on a diet supplemented with a microencapsulated blend of organic acids and botanicals in a necrotic enteritis challenge model.
| Term ID | Pathway description1 | Peptide count | FDR2 |
|---|---|---|---|
| hsa04152 | AMPK signaling pathway | 24 | 3.07E-21 |
| hsa04010 | MAPK signaling pathway | 31 | 1.07E-20 |
| hsa04910 | Insulin signaling pathway | 24 | 1.07E-20 |
| hsa04660 | T cell receptor signaling pathway | 21 | 1.65E-19 |
| hsa04722 | Neurotrophin signaling pathway | 22 | 1.65E-19 |
| hsa04931 | Insulin resistance | 21 | 4.91E-19 |
| hsa04920 | Adipocytokine signaling pathway | 17 | 6.92E-17 |
| hsa04150 | mTOR signaling pathway | 21 | 1.26E-16 |
| hsa04068 | FoxO signaling pathway | 20 | 1.61E-16 |
| hsa04140 | Autophagy - animal | 19 | 1.13E-15 |
| hsa04218 | Cellular senescence | 20 | 2.89E-15 |
| hsa04066 | HIF-1 signaling pathway | 17 | 6.03E-15 |
| hsa04922 | Glucagon signaling pathway | 17 | 7.65E-15 |
| hsa04211 | Longevity regulating pathway | 16 | 1.99E-14 |
| hsa04064 | NF-kappa B signaling pathway | 16 | 4.09E-14 |
| hsa04151 | PI3K-Akt signaling pathway | 25 | 8.39E-14 |
| hsa04510 | Focal adhesion | 20 | 1.17E-13 |
| hsa04012 | ErbB signaling pathway | 15 | 1.40E-13 |
| hsa04668 | TNF signaling pathway | 16 | 2.76E-13 |
| hsa04919 | Thyroid hormone signaling pathway | 16 | 6.39E-13 |
| hsa04370 | VEGF signaling pathway | 13 | 7.77E-13 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 14 | 8.81E-13 |
| hsa04932 | Non-alcoholic fatty liver disease | 17 | 1.49E-12 |
| hsa04371 | Apelin signaling pathway | 16 | 3.60E-12 |
| hsa04662 | B cell receptor signaling pathway | 13 | 4.81E-12 |
| hsa04213 | Longevity regulating pathway | 12 | 1.74E-11 |
| hsa04659 | Th17 cell differentiation | 14 | 1.96E-11 |
| hsa04664 | Fc epsilon RI signaling pathway | 12 | 4.15E-11 |
| hsa04714 | Thermogenesis | 18 | 7.24E-11 |
| hsa04072 | Phospholipase D signaling pathway | 15 | 1.15E-10 |
| hsa05418 | Fluid shear stress and atherosclerosis | 14 | 4.24E-10 |
| hsa04210 | Apoptosis | 14 | 4.77E-10 |
| hsa04071 | Sphingolipid signaling pathway | 13 | 8.69E-10 |
| hsa04921 | Oxytocin signaling pathway | 14 | 1.43E-09 |
| hsa04062 | Chemokine signaling pathway | 15 | 1.63E-09 |
| hsa04014 | Ras signaling pathway | 16 | 3.84E-09 |
| hsa04666 | Fc gamma R-mediated phagocytosis | 11 | 7.73E-09 |
| hsa04657 | IL-17 signaling pathway | 11 | 1.04E-08 |
| hsa04520 | Adherens junction | 10 | 1.28E-08 |
| hsa01522 | Endocrine resistance | 11 | 1.33E-08 |
| hsa04620 | Toll-like receptor signaling pathway | 11 | 2.48E-08 |
| hsa05145 | Toxoplasmosis | 11 | 4.48E-08 |
| hsa04926 | Relaxin signaling pathway | 11 | 2.37E-07 |
| hsa04144 | Endocytosis | 14 | 3.39E-07 |
| hsa04360 | Axon guidance | 12 | 4.47E-07 |
| hsa04658 | Th1 and Th2 cell differentiation | 9 | 8.20E-07 |
| hsa04912 | GnRH signaling pathway | 9 | 8.20E-07 |
| hsa04650 | Natural killer cell mediated cytotoxicity | 10 | 1.33E-06 |
| hsa04622 | RIG-I-like receptor signaling pathway | 8 | 1.71E-06 |
| hsa04015 | Rap1 signaling pathway | 12 | 2.11E-06 |
| hsa04621 | NOD-like receptor signaling pathway | 11 | 2.12E-06 |
| hsa04530 | Tight junction | 11 | 2.22E-06 |
| hsa04810 | Regulation of actin cytoskeleton | 12 | 2.22E-06 |
| hsa04310 | Wnt signaling pathway | 10 | 3.99E-06 |
| hsa04670 | Leukocyte transendothelial migration | 9 | 4.52E-06 |
| hsa04110 | Cell cycle | 9 | 9.10E-06 |
| hsa04611 | Platelet activation | 9 | 9.10E-06 |
| hsa04750 | Inflammatory mediator/regulation TRP channel | 8 | 9.55E-06 |
| hsa04915 | Estrogen signaling pathway | 9 | 1.55E-05 |
| hsa04270 | Vascular smooth muscle contraction | 8 | 5.18E-05 |
| hsa04540 | Gap junction | 7 | 5.75E-05 |
| hsa04022 | cGMP-PKG signaling pathway | 9 | 5.97E-05 |
| hsa04630 | Jak-STAT signaling pathway | 9 | 5.97E-05 |
| hsa04720 | Long-term potentiation | 6 | 9.60E-05 |
| hsa04024 | cAMP signaling pathway | 9 | 0.00024 |
| hsa04141 | Protein processing in ER | 8 | 0.00035 |
| hsa04728 | Dopaminergic synapse | 7 | 0.0005 |
| hsa04390 | Hippo signaling pathway | 7 | 0.0012 |
| hsa01200 | Carbon metabolism | 6 | 0.0016 |
| hsa04145 | Phagosome | 6 | 0.0046 |
| hsa01100 | Metabolic pathways | 22 | 0.0051 |
| hsa04217 | Necroptosis | 6 | 0.0061 |
| hsa04020 | Calcium signaling pathway | 6 | 0.0113 |
1
Pathways with five or fewer significant peptides or those related to cancer and viral infections were removed.
2
False discovery rate.