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. 2022 Jan 28;298(3):101643. doi: 10.1016/j.jbc.2022.101643

Figure 1.

Figure 1

Eukaryotic heme biosynthesis is initiated by aminolevulinic acid synthase.A, aminolevulinic acid synthase (dark blue circle) initiates heme biosynthesis in the mitochondrion of nonplant eukaryotes by catalyzing the condensation of glycine and succinyl-CoA to ALA (red labels). Other enzymes involved in the pathway are indicated in light blue circles whereas intermediates are labeled in black. B, reaction schematic for ALAS enzymes in which cofactor pyridoxal phosphate and active site lysine (K391) are used for the condensation reaction. Residue numbering is based on human ALAS2. ALA, aminolevulinic acid; ALAS, aminolevulinic acid synthase.