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. 2022 Jan 21;298(3):101617. doi: 10.1016/j.jbc.2022.101617

Figure 3.

Figure 3

Extrinsic regulation of ferroptosis.A, E-cadherin/hippo signaling and the downstream YAP/TAZ pathways mediate ferroptosis insensitivity with increased cell contact; MCT1-mediated uptake of lactate (red dots) regulates ferroptosis via ACSL4 and SCD1; availability of Arginine promotes sensitivty to ferroptosis, while CoA diminishes sensitivity to ferroptosis; and supplementation with Selenium (Se) enables ferroptosis resistance through GPX4. B, unlike blood, which contains greater levels of free iron, the lymph provides a reducing and antioxidant-rich environment with higher levels of GSH, Vit E, and vesicles containing oleic acid, all of which protect metastasizing tumor cells from ferroptosis. ACSL4, acyl-CoA synthetase long-chain family member 4; CAF, cancer associated fibroblasts; CoA, coenzyme A; GSH, Glutathione; HCAR1, Hydroxycarboxylic acid receptor 1; MCT1, monocarboxylate transporter 1; P, Phosphate; SCD1, stearoyl-CoA desaturase enzyme 1; TAZ, transcriptional co-activator with PDZ-binding motif; U, Ubiquitin; Vit E, Vitamin E; YAP, Yes-associated protein 1.