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ALKBH6 has an unusual active center.A, the interaction network around Tris and Ni2+ in the ALKBH6∙Ni2+∙Tris structure, Fo-Fc (3.0 σ, gray mesh). B, the interaction network around α-KG (Fo-Fc, 3.0 σ, gray mesh) and distribution of binding sites. C, binding analysis of ALKBH6 or mutant A with α-KG (mutant A: N103A/Y105A/R218A). The experiments were repeated three times.
