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. 2021 Dec 20;14:182–205. doi: 10.1016/j.bioactmat.2021.11.027

Fig. 5.

Fig. 5

A) Principle scheme of the synthesis of quercetin-modified Zr-MOF nanoparticle (Zr-MOF-QU) nanocarriers and schematic illustration of the nanoparticle-based therapeutic principle for dual sensitization radiation therapy of tumors and the mechanism of relieving hypoxia in the tumor microenvironment B) Tumor volumes of different groups in A549 tumor-bearing mice. C) Representative results of an A549 MTT assay in different groups, including a control, RT, QU + RT, Zr-MOF + RT, and Zr-MOF-QU + RT. The results from 24 to 48 h show a statistically significant difference. The p values were calculated by Student's t-test. *p < 0.05, **p < 0.01, ***p < 0.001. D), E) Intensity expression levels of HIF-1a and CA IX in control, RT, QU + RT, Zr-MOF + RT, and Zr-MOF-QU + RT groups. *p < 0.05, **p < 0.01, ***p < 0.001. Adapted with permission [136]. Copyright 2019, American Chemical Society.