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. 2021 Dec 20;14:182–205. doi: 10.1016/j.bioactmat.2021.11.027

Fig. 6.

Fig. 6

A) Effects of early CLT and CLT-AN (Celastrol-albumin) treatment on 24-h urinary protein excretion in anti-Thy1.1 nephritic rats on day 5 after disease induction. B) Glomerular histology revealed by PAS staining of kidney tissue sections from anti-Thy1.1 nephritic rats on day 5 after early treatment with CLT and CLT-AN; the scale bars represent 20 μm. C) Effects of early CLT and CLT-AN treatment on total glomerular cellularity on day 5 after disease induction. D) Effects of early CLT or CLT-AN treatment on ECM deposition on day 5 after disease induction. For each animal group, 150 glomeruli were analyzed and ECM deposition was graded semi-quantitatively, as described in Methods. Anti-inflammatory effects of CLT and CLT-AN in anti-Thy1.1 nephritic rats. Real-time PCR analysis of renal mRNA levels of MCP-1 E), ICAM-1 F), IL-6 G), IL-1β H) in anti-Thy1.1 nephritic rats on day 1 after treatment with CLT or CLT-AN. Data are shown as normalized fold expressions relative to normal group using β-actin mRNA as internal control. The data in A), C), and H) are mean ± s.d. (n = 5), and those in I) are mean ± s.d. (n = 3). Adapted with permission [143]. Copyright 2017, Springer Nature.