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. 2021 Dec 20;14:182–205. doi: 10.1016/j.bioactmat.2021.11.027

Fig. 9.

Fig. 9

A) Transmission electron microscopy image of pegylated melanin nanoparticles (PEG-MeNPs). B) Effect of PEG, SOD, MeNPs, and PEG-MeNPs on EPR signals of DEPMPO-OOH. C) O2 production from KO2 solution (100 μM) with vs without PEG-MeNPs. The inset is a digital image of the PEG-MeNP solution before vs after KO2 addition. The assay was performed in triplicate. D) O2 production from KO2 solution (100 μM) catalyzed by SOD vs PEG-MeNPs. The concentration of PEG-MeNPs for catalysis is 0.1 nM. Assay was performed in triplicate. E) Levels of ROS in LPS-stimulated macrophages with different PEG-MeNP concentrations. F) Representative images of TTC-stained brain slices from different groups (*p < 0.05 and **p < 0.01 vs saline control). Adapted with permission [171]. Copyright 2017, American Chemical Society.