Table 1.
Significantly differential metabolic pathways between insomnia disorder patients and healthy controls.
| Pathway | Total | Hits | Raw p | - Log (p) | Holm p | FDR | Impact |
|---|---|---|---|---|---|---|---|
| Pantothenate and CoA biosynthesis | 27 | 1 | 0.054887 | 2.9025 | 1 | 1 | 0.18014 |
| Beta-Alanine metabolism | 28 | 1 | 0.056872 | 2.8669 | 1 | 1 | 0 |
| Glutathione metabolism | 38 | 1 | 0.076545 | 2.5699 | 1 | 1 | 0.0019 |
| Arginine and proline metabolism | 77 | 1 | 0.15016 | 1.8961 | 1 | 1 | 0.00447 |
| Cysteine and methionine metabolism | 56 | 4 | 0.0014079 | 6.5656 | 0.11263 | 0.11263 | 0.06354 |
| Arginine and proline metabolism | 77 | 2 | 0.15485 | 1.8653 | 1 | 1 | 0.01841 |
| Taurine and hypotaurine metabolism | 20 | 1 | 0.16837 | 1.7816 | 1 | 1 | 0.03237 |
| Selenoamino acid metabolism | 22 | 1 | 0.18364 | 1.6948 | 1 | 1 | 0 |
| Alanine, aspartate and glutamate Metabolism | 24 | 1 | 0.19863 | 1.6163 | 1 | 1 | 0.05698 |
| Fatty acid elongation in mitochondria | 27 | 1 | 0.22063 | 1.5113 | 1 | 1 | 0 |
| Pantothenate and CoA biosynthesis | 27 | 1 | 0.22063 | 1.5113 | 1 | 1 | 0.18014 |
| Beta-Alanine metabolism | 28 | 1 | 0.22783 | 1.4791 | 1 | 1 | 0 |
| Steroid hormone biosynthesis | 99 | 2 | 0.22826 | 1.4773 | 1 | 1 | 0.04349 |
| Glutathione metabolism | 38 | 1 | 0.29647 | 1.2158 | 1 | 1 | 0.0019 |
| Histidine metabolism | 44 | 1 | 0.33481 | 1.0942 | 1 | 1 | 0.04715 |
| Phenylalanine metabolism | 45 | 1 | 0.341 | 1.0759 | 1 | 1 | 0 |
| Primary bile acid biosynthesis | 47 | 1 | 0.35322 | 1.0407 | 1 | 1 | 0.00027 |
| Glycine, serine and threonine Metabolism | 48 | 1 | 0.35925 | 1.0237 | 1 | 1 | 0.0342 |
| Fatty acid biosynthesis | 49 | 1 | 0.36523 | 1.0072 | 1 | 1 | 0 |
| Fatty acid metabolism | 50 | 1 | 0.37115 | 0.99115 | 1 | 1 | 0.02959 |
| Aminoacyl-tRNA biosynthesis | 75 | 1 | 0.50317 | 0.68682 | 1 | 1 | 0 |