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. 2022 Feb 9;298(3):101701. doi: 10.1016/j.jbc.2022.101701

Figure 4.

Figure 4

Disruption of MuvB complex triggers activation of lineage-specific genes.A and B, heatmap showing the expression levels of genes involved in germ layer specification, pluripotency maintenance and cell cycle progression in ESCs individually deficient for Lin9, Lin37, Lin52, or Lin54. C, RNA-Seq data were verified by RT-qPCR. RNA was obtained from Lin54F/F ESCs 3 days after Cre transfection. The RT-qPCR data of selected genes were normalized to β-actin. Error bars denote standard deviation of triplicate data, n = 3. ESC, embryonic stem cell; MuvB, multivulva class B.