Table 1.
Histological grading according to the cell type and tissue response.
| Response | Score *(phf = per high powered (x400) field) |
||||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |
| Polymorphonuclear cells | 0 | Rare, 1-5/phf* | 6-10/phf | Heavy infiltrate | Packed |
| Lymphocytes | 0 | Rare, 1-5/phf | 6-10/phf | Heavy infiltrate | Packed |
| Plasma cells | 0 | Rare, 1-5/phf | 6-10/phf | Heavy infiltrate | Packed |
| Macrophages | 0 | Rare, 1-5/phf | 6-10/phf | Heavy infiltrate | Packed |
| Giant cells | 0 | Rare, 1-2/phf | 3-5/phf | Heavy infiltrate | Packed |
| Necrosis | 0 | Minimal | Mild | Moderate | Marked |
| Fibrinous exudates | 0 | Minimal | Mild | Moderate | Marked |
| Tissue degeneration | 0 | Minimal | Mild | Moderate | Marked |
| Neovascularization | 0 | Minimal capillary proliferation focal, 1-3 buds | Groups of 4–7 capillaries with supporting fibroblastic structures | Broad band of capillaries with supporting structures | Extensive band of capillaries with supporting fibroblastic structures |
| Fibrocytes/fibroconnective tissue, fibrosis | 0 | Narrow band | Moderately thick band | Thick band | Extensive band |
| Fatty infiltrate | 0 | Minimal amount of fat associated with fibrosis | Several layers of fat and fibrosis | Elongated and broad accumulation of fat cells about the implant site | Extensive fat surrounding the implant |
| Additional Parameters | |||||
| Overall Inflammation, Inflammation within Gingiva (away from membrane), Inflammation Associated with membrane/Membrane Area, Inflammation Associated with Bone Filler, New Bone Growth, Soft Tissue Infiltration, Hemorrhage, Amount of Void/Empty Space | Absent | Minimal | Mild | Moderate | Marked |