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. 2022 Feb 17;8:759585. doi: 10.3389/fvets.2021.759585

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Copyright © 2022 Schneider, Sansom, Guo, Furuya, Weeks and Kornegay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fatty infiltration was a prominent feature in older Golden Retriever muscular dystrophy (GRMD) dogs. (A) A section of left ventricle free wall from a 3-years-old female GRMD dog shows large bands of fat (non-staining vacuolated tissue) replacing normal myocardial muscle (red) and predominating over fibrosis (blue). (B) In some cases, fatty infiltration was more diffuse with individual or small clusters of fat cells scattered throughout the myocardium (male, 1-year-old). (C) In several dogs, the RV showed striking mid-myocardial replacement by bands of fat with minimal fibrotic tissue (male, 3.5-years-old). In these trichrome-stained sections, muscle fibers = red, collagen = blue, and fat cells = non-staining vacuolated tissue; × 10 original magnification.