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Repair of large-sized bone defects based on BRU-loaded DBM framework. A) Preparation of BRU-DBM scaffold (i-ii), and surgical procedures of implanting BRU-DBM scaffold (iii-v). B–C) X-ray (B) and micro-CT (C) examinations of regenerated bone tissue after implantation for 0-month, 1-month, and 3-months. D) Quantitative indexes of bone volume (BV), bone volume/total volume (BV/TV), bone surface (BS), and number of bone trabecula (Tb. N).
