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. 2022 Feb 17;13:813849. doi: 10.3389/fmicb.2022.813849

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Copyright © 2022 Leopold, Abdelraouf, Nicolau, Agresta, Johnson, Teter, Dunne, Broadwell, van Belkum, Schechter, Sodergren and Weinstock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of piperacillin-tazobactam (TZP) on the Alpha Diversity. The alpha diversity of each mouse in each time point was measured using Pielou’s evenness, absolute number of OTUs (richness), and Shannon diversity index (diversity). Significant differences between two time points are indicated by asterisks where p > 0.05 = ns, p < 0.05 = *, p < 0.01 = **, p < 0.001 = ***, and p < 0.0001 = ****. Panel (A) shows results obtained during the TZP1 study, whereas panel (B) displays the results obtained during the TZP2 study.