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. 2022 Feb 17;13:815833. doi: 10.3389/fimmu.2022.815833

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Copyright © 2022 Lage, Rocco, Laidlaw, Rupert, Galindo, Kellogg, Kumar, Poon, Wortmann, Lisco, Manion and Sereti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complement deposition on circulating blood monocytes from COVID-19 stratified by disease status. The mean fluorescence intensity (MFI) of C1q (A), C3 (B), CD55 (C) and CD59 (D) expression on circulating blood monocytes was compared among healthy controls (HC) (n = 14), COVID-19 Mild to Moderate patients (n = 30) and Severe patients (n = 12) by flow cytometry. Data are presented as Fold change over their respective experimental HC mean, and graphs depict median and interquartile range. Data were analyzed using the Kruskal-Wallis test. **P < 0.01, ****P < 0.0001; ns, not significant.