Fig. 3.
Minimum required proportion of genetically resistant animals for achieving disease elimination through gene editing and vaccination combined, depending on vaccine effectiveness εV and exposure probability. Dark bars: εV = 0.7, medium bars: εV = 0.5; light bars: εV = 0.3. Different colors refer to different distribution scenarios (see Table 1) with blue = optimum, black = comprehensive, green = concentrated and yellow = unregulated. The proportion of edited animals in the concentrated scenarios is chosen at the smallest possible proportion for elimination under each scenario, resulting in a Pe of 0.75 for scenarios A and C (green bars), a Pe of 0.5 for scenario B (green bars, purple fill), and a Pe of 0.1 for scenario D (green bars, red fill). An average transmission potential of R0 = 1.5 was assumed.