Table 1.

Results of phylogenetic tests

Gene	Start position	Gene source	LogLik H0	LogLik Ha	P value	FDR	P value for improved status calls
ZCWPW1	chr7:100400826	1	−65.941	−53.35647	4.651e−05	0.0064	1.948e−03
MEI1	chr22:41699503	3,1	−54.200	−44.779	8.442e−04	0.0586	NA
ZCWPW2	chr3:28348721	1	−67.711	−60.146	4.437e−03	0.2055	5.171e−06
TEX15	chr8:30831544	1	−138.430	−131.764	9.760e−03	0.3391	8.682e−02
FBXO47	chr17:38936278	2	−53.678	−47.559	1.566e−02	0.4354	1.566e−02

We focused on the five genes that had an FDR ≤ 50%, improved the ortholog status calls, and reran the phylogenetic tests for four of them (all but MEI1, which turned out to be present in all species considered; see Methods). Gene source refers to the criterion by which the gene was originally included among our lists of candidates: 1) It is coexpressed with PRDM9 in single-cell mouse testes data (31), or 2) variants assigned to the gene are associated with variation in recombination phenotypes in humans (33), or 3) the gene was previously known to have a role in mammalian meiotic recombination from functional studies (32) (see Methods). Start positions are based on the human reference genome GRCh38/hg38. NA, not applicable.