Fig. 3.
Ascr#7 decreases the number of ST2hi Th2 cells. (A) Single-cell transcriptomes of libraries from lungs of control mice or mice treated with synthetic ascr#7 were projected onto a UMAP of the scRNA-seq libraries from lungs of control mice or mice treated with ascr#7, as indicated in Fig. 1A, and colored according to cellular subset. (B) Absolute numbers of each cellular subset by treatment condition. White bars indicate cells of mice without immunization (no immunization). Gray bars indicate cells of mice treated with OVA/alum (control). Black bars indicate cells of mice treated with OVA/alum plus ascr#7 (ascr#7). (C) Expression of Gata3 (Upper) and Il1rl1 (Lower) projected onto a UMAP. (D) Expression of Il1rl1 projected onto violin plots. **P < 0.01, ***P < 0.001; UMI, unique molecular identifiers.