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. 2022 Mar 2;7(4):396–406. doi: 10.1001/jamacardio.2022.0001

Figure 2. Combinatorial Murine Models of Collagen Deficiency Demonstrate Vascular Phenotypes.

Figure 2.

A, Survival curve demonstrates Col5a1+/− and Col3a1+/−:Col5a1+/− mice exhibit sudden death due to aortic rupture (log-rank P < .005). B, Postmortem Col5a1+/− and Col3a1+/−:Col5a1+/− mice demonstrate hemothorax indicative of aortic failure. Latex-injected murine aortas (C) and parasternal long-axis echocardiographic still images of genotypes (D; white arrowheads indicate aortic root). E, Aortic root dimensions by genotype.