Table. Demographics of SCAD Discovery and Replication Cohorts.
| Characteristic | No. (%) | P value | |
|---|---|---|---|
| Discovery (n = 32) | Replication (n = 98) | ||
| Age, mean (SD), y | 48.41 (8.76) | 47.74 (10.09) | .74 |
| Race | |||
| African American | 1 (3.1) | 3 (3.1) | .96 |
| Asian | 1 (3.1) | 5 (5.1) | |
| White | 29 (90.6) | 87 (88.8) | |
| Othera | 1 (3.1) | 3 (3.1) | |
| Female | 26 (81.2) | 83 (84.7) | .86 |
| Male | 6 (18.8) | 15 (15.3) | .86 |
| BMI, mean (SD) | 24.99 (4.26) | 27.55 (6.01) | .92 |
| Current or former smoker | 5 (16.7) | 26 (26.8) | .38 |
| Hypertension | 14 (46.7) | 39 (39.48) | .65 |
| Hypercholesterolemia | 13 (43.3) | 26 (26.5) | .13 |
| Diabetes | 0 | 1 (1.0) | >.99 |
| Cardiomyopathy | 3 (10.0) | 9 (9.1) | >.99 |
| Recurrent SCAD | 7 (23.3) | 9 (9.1) | .08 |
| Fibromuscular dysplasia | 10 (33.3) | 31 (32.3) | >.99 |
| Any aneurysm | |||
| None | 32 (100.0) | 91 (92.9) | .79 |
| Aortic | 0 | 2 (2.0) | |
| Cervical | 0 | 1 (1.0) | |
| Intracranial | 0 | 1 (1.0) | |
| Mesenteric | 0 | 1 (1.0) | |
| Splenic | 0 | 2 (2.0) | |
| Other dissection | |||
| None | 31 (96.9) | 90 (91.8) | .22 |
| Cervical | 0 | 6 (6.1) | |
| Intracranial | 1 (3.1) | 0 | |
| Mesenteric | 0 | 1 (1.0) | |
| Aortic | 0 | 1 (1.0) | |
| Therapy | |||
| Medical | 13 (40.6) | 69 (70.4) | .001 |
| PCI | 17 (53.1) | 25 (25.5) | |
| Surgical | 0 | 4 (4.1) | |
| None | 2 (6.2) | 0 | |
| STEMI or NSTEMI | |||
| NSTEMI | 11 (34.4) | 61 (62.2) | .02 |
| STEMI | 19 (59.4) | 34 (34.7) | |
| No MI | 2 (6.2) | 3 (3.0) | |
| Activity | |||
| Emotional stress | 4 (12.5) | 17 (17.3) | .498 |
| Exercise | 11 (34.4) | 32 (32.7) | |
| Postpartum | 1 (3.1) | 3 (3.0) | |
| Rest | 14 (43.8) | 30 (30.3) | |
| Location 1 | |||
| LAD | 23 (71.9) | 58 (58.6) | .31 |
| LCx | 0 | 2 (2.0) | |
| D1 | 0 | 3 (3.0) | |
| OM | 2 (6.2) | 18 (18.2) | |
| PDA | 1 (3.1) | 7 (7.1) | |
| RCA | 4 (12.5) | 8 (8.1) | |
| Location 2 | |||
| LAD | 2 (6.2) | 2 (2.0) | .73 |
| LCx | 0 | 2 (2.0) | |
| D1 | 3 (9.4) | 5 (5.1) | |
| D2 | 0 | 1 (1.0) | |
| D3 | 0 | 1 (1.0) | |
| OM | 2 (6.2) | 14 (14.1) | |
| PDA | 1 (3.1) | 6 (6.1) | |
| RCA | 2 (6.2) | 6 (6.1) | |
| No SCAD location 2 | 22 (68.8) | 61 (62.2) | |
| Tortuosity = 1 | 25 (86.2) | 44 (48.4) | .001 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); D1, first diagonal artery; D2, second diagonal artery; D3, third diagonal artery; LAD, left anterior descending artery; LCx, left circumflex artery; MI, myocardial infarction; NSTEMI, non–ST-segment elevation myocardial infarction; OM, obtuse marginal artery; PCI, percutaneous coronary intervention; PDA, posterior descending artery; RCA, right coronary artery; SCAD, spontaneous coronary artery dissection; STEMI, ST-segment elevation myocardial infarction.
a
Other includes Middle Eastern/North African and Pacific Islander.